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KMID : 1145520220080020087
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Journal of Radiopharmaceuticals and Molecular Probes
2022 Volume.8 No. 2 p.87 ~ p.93
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The Development of Radiopharmaceutical Synthesizer and its FDG Synthesis Verification
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Kim Jong-Min
Cheong Il-Koo
Park Chan-Soo
Kil Hee-Seup
Lee Cheol-Soo
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Abstract
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[18F]FDG is known as the most widely used radiopharmaceutical in the imaging field of nuclear medicine worldwide. With the introduction of PET equipment, the demand for [18F]FDG has increased and the production volume has also increased. However, in order to increase production, the use of 18F radioisotope must be increased or [18F]FDG must be synthesized in high yield. Therefore, in order to meet the high yield and purity of radiopharmaceuticals, a radiopharmaceutical automatic synthesizer was required. As the use of [18F]FDG increased, automated synthesizer manufacturers supplied various types of radiopharmaceutical automated synthesizers to the market. In this study, we developed a commercialized [18F]FDG radiopharmaceutical automatic synthesizer (sCUBE FDG) using a disposable cassette type that complies with GMP developed by FutureChem, a leading radiopharmaceutical company. We used sCUBE FDG to verify the production process, radiopharmaceutical’s quality (radiochemical purity, etc.), and radiochemical yield of [18F]FDG. As a result of optimizing the automatic synthesis process and synthesizing a total of 30 times, the production time was 35 ± 3 minutes and the average production yield was 65.6%.
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KEYWORD
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[18F]FDG, PET imaging, Automated synthesis, Disposable cassette
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